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L-arginine , a semi-essential amino acid, serves as the substrate for nitric oxide synthase (NOS) enzymes, which convert it to nitric oxide and L-citrulline
One of the most overlooked facts is that many patients are not stopping because they gave up. They are stopping because coverage changed, formularies shifted, prior authorizations were denied, side effects were unmanaged, or costs became impossible
This has led scientists to explore the potential of GLP-1 receptor agonists in reducing addictive behaviors
Since embryos or infants produced through MRT carry maternal mtDNA, future studies should also focus on combining MRT with mtDNA gene editing to reduce mtDNA carriage to undetectable levels, providing potential directions for future research [138, 139]
