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The review traced the developmental history of GLP-1 research from the identification of the proglucagon gene in 1982 through to the contemporary landscape of GLP-1-based therapeutics across obesity, cardiovascular disease, NAFLD, neurodegeneration, and cancer biology
Therefore, the decrease in the differentiation of L-cells may be due to the reduction in stem cell proliferative capacity induced by chronic hyperglycemia [31]
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