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However, in rare cases where central obesity is not present, liposuction may still be considered for individuals with a higher BMI.3,37,40 Although many studies reported improving the disease's symptoms, such as reduction of spontaneous pain, bruising, and mobility impairment, there is still not enough evidence to support liposuction as the gold standard in treating lipedema.37,54 It is also important to highlight that liposuction carries risks and potential complications, including post-procedural pain, infection, prolonged recovery, scarring, bruising, ecchymosis, edema, and substantial financial costs, which must be carefully considered in clinical decision-making.54 Bariatric surgery Bariatric surgery may be considered for individuals with lipedema and a BMI 40 kg/m2, and potentially for those with a BMI between 3540 kg/m2

based on readout pacing, I would project an NDA filing in late 2026 and a possible approval window in 2027 if results hold

Prioritizing protein, fiber, and nutrient-dense whole foods while staying active (even through moderate walking) amplifies results

S., Pollak, M

2007: A study in 36 people (average age 63) with coronary artery disease found that taking 500 mg of acetyl-L-carnitine plus 200 mg of alpha-lipoic acid twice daily for 8 weeks lowered systolic blood pressure by 9 mmHg in those with coronary artery disease and high blood pressure, which was significant compared to placebo