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Schallreuter KU

Mechanisms include: Restoration of endothelial nitric oxide synthase (eNOS) Upregulation of VEGF and FGF-2 (fibroblast growth factor 2) Reduction of oxidative stress and cytokine-induced apoptosis BPC-157 preserved endothelium-dependent vasodilation via upregulation of eNOS and suppression of vascular inflammation. Gwyer Findlay et al., Peptides 4

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Bolognia J, Schaffer JV, Cerroni L

Also, mutant C9orf72-derived astrocytes downregulate secretion of several antioxidants and induce cellular senescence (Birger et al., 2019)