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Preliminary Study Questions Carnitines Role in Cardiovascular Disease, Generates Misleading Media Headlines A recent investigational study published in the journal Nature Medicine examined levels of a compound called trimethylamine-N-oxide (TMAO) in relationship to microbial metabolism of carnitine in the gut
Histology revealed better collagen organization, higher cellularity, and more extensive vascularization
Evidence and Licensing Limits GLP-1 medicines are licensed for adults living with overweight or obesity
Otherwise, serious adverse events were reported in ~6% of participants and were evenly distributed across tirzepatide and placebo groups
For patients with type 2 diabetes, other medication classes with fewer gastrointestinal effects might be preferable, such as SGLT-2 inhibitors or DPP-4 inhibitors
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