Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division
At first, weight loss was seen simply as a bonus effect in diabetics, but it foreshadowed the repurposing of GLP-1 drugs for obesity alone, a concept realized years later
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Back Moody, AJ, Holst, JJ, Thim, L, Lindkaer Jensen, S (5 Feb 1981) 'Relationship of glicentin to proglucagon and glucagon in the porcine pancreas', Nature , 289, 514-16
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