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Serious GLP-1 drug side effects to watch for Like any medication, GLP-1 drugs aren't without risks
In March 2026, the TRANSCEND-T2D-1 trial showed retatrutide delivered up to 2.0% A1C reduction and nearly 17% weight loss at 40 weeks with no plateau observed, meaning participants were still losing weight at the end of the trial
The second shields the molecule from degradation by DPP-4 enzymes, which would otherwise break it down within minutes
Should phentermine no longer be appropriate for a patient, alternative weight loss strategies can be explored to ensure continued success
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