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This is more critical with tirzepatide due to its stronger glucose-lowering effect

GLP-1 signals through receptors primarily in the pancreas, gut and brain to increase insulin signalling and reduce food intake 58

Nrf2 upregulates the expression of dozens of cytoprotective enzymes, including GCL itself, creating a compensatory response to oxidative stress

Interestingly, FGF21, SREBP-1c, and FAS mRNA in the liver tissues of the model group of mice and protein expression was increased compared with the control group, while liver kinase B1 (LKB1) mRNA expression was reduced

Most insurers, including Medicare Advantage plans, now require it