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Most common are mild-to-moderate, dose-dependent gastrointestinal events: nausea, diarrhea, vomiting, abdominal pain, constipation, decreased appetite, and dyspepsia[1][4][5]

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(2001) investigated AOD9604 in obese Zucker rats and observed that chronic administration was associated with reduced body weight gain without changes in IGF-1 levels or glucose tolerance, distinguishing its activity profile from that of full-length growth hormone [1]

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Overall, incorporation of aza-residues at the peptide N-terminus substantially extended systemic exposure relative to native GLP-1, underscoring the stabilizing effect of these modifications