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Obesity-related heart failure with a preserved ejection fraction: the mechanistic rationale for combining inhibitors of aldosterone, neprilysin, and sodium-glucose cotransporter-2

Both native and cloned receptors signal through the activation of both adenylyl cyclase and phospholipase C (76, 129)

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234 Alarmingly, contamination with heavy metals, pesticides, or undisclosed pharmaceuticals like corticosteroids has been reported in various herbal products, amplifying toxicological risks