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The proposed direct vascular mechanisms, supported by preclinical and clinical data, include the following: Endothelial protection: GLP-1 receptor agonists promote nitric oxide production, vasodilation, and angiogenesis while inhibiting oxidative stress in vascular endothelial cells Plaque stabilization: Reduced matrix metalloproteinase activity prevents fibrous cap degradation

(1991), the ratio of esterified short-chain L-carnitine to free L-carnitine reaches a maximum in tissues (liver, brain and heart) of the chicken embryos on the 18th day of incubation, thereby suggesting that the fatty acid oxidation is inevitable for energy production in embryos

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