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When combined with a lower-calorie diet, the man saw a 32.5% reduction in total body weight

These can contribute to fluid loss, so aim to limit them or balance them with extra water (12)

This difference becomes especially important given that GLP-1 therapies are typically used long-term, where monthly savings quickly add up

In line with this hypothesis, an observational study of 200 adults with type 1 diabetes demonstrated improvements in albuminuria and in eGFR with SGLT2i use over 12 months among adults with a baseline eGFR 7000 participants identified a 2.8-fold greater risk of DKA with SGLT2i use compared with placebo in adults with type 1 diabetes [44]

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