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When glutathione becomes oxidized while neutralizing free radicals, vitamin C helps restore it back to its active, protective form

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Topical effects are usually mild and local: redness, tingling, dryness, or transient irritation, more common above 4% concentration

Thomas DA, Faderl S, Cortes J, OBrien S, Giles F, Garcia G, Kornblau S, Andreeff M , Beran M, Verstovsek S, Pierce S, Letvak L, Salvado A, Champlin R, Kantarjian H

The cell suspension was passed through a 100-m cell strainer and then centrifuged at 72.4 g av for 5 min at room temperature