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Accessed 1 Mar 2022
It works in a similar way to the naturally occurring GLP-1 hormone, which is released after eating and is involved in: appetite regulation feelings of fullness insulin release blood-glucose regulation the movement of food through the stomach By activating GLP-1 receptors, semaglutide can reduce hunger, increase satiety and help people feel satisfied after eating smaller portions
First, an amino acid substitution at position 8 (alanine replaced with aminoisobutyric acid) provides resistance to DPP-4 degradation, the primary enzyme responsible for native GLP-1 breakdown
The WSCA used in this experiment was provided by Daicel Corporation (Osaka, Japan), and its properties are shown in Supplementary Fig
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