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Gillett HR, Arnott IDR, McIntyre M, et al

Both in vitro and in vivo studies showed that overexpression of TH, a rate-limiting enzyme in dopamine biosynthesis, induces degeneration of dopaminergic neurons [42, 43]

They can be used even when you are taking a tyrosinase inhibitor holiday: Aloesin Dimethylmethoxy Chromanyl Palmitate Flavonoids (A large family of compounds that includes resveratrol) Oils with unsaturated fatty acids (see list below of oils) Natural Oils To Lighten Skin Oils with high concentrations of unsaturated fatty acids are also considered natural tyrosinase inhibitors

doi: 10.1016/j.bbcan.2016.09.006 234 CorradettiMNInokiKBardeesyNDePinhoRAGuanKL

Nature Communications, 16, Article 3389.