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Subjects came to the clinic the day before dosing and fasted overnight for 10 h before dosing (water ad libitum was allowed until 1 h before dosing)

Besides, our study was neither randomized nor blinded, leading to potential bias, whose influence should be mitigated by matching for relevant confounders

Sterne JAC, Savovi J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials