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(2024d, February 29)

Both GLP-1 and exendin-4 control blood glucose through the stimulation of glucose-dependent insulin secretion, the inhibition of glucagon secretion, and delayed gastric emptying [34, 46, 47], which facilitate the decrease in blood glucose in type 1 and type 2 diabetic patients [48]

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For contextual class comparisons, the eMC SmPCs for semaglutide (Wegovy/Ozempic) and tirzepatide (Mounjaro) provide authoritative information on hypersensitivity and injection site reactions associated with approved GLP-1-based agents, and are relevant reference points for clinicians managing similar symptoms in patients receiving retatrutide in a trial setting