This program evaluated the efficacy and safety of oral semaglutide in patients with DM2 from monotherapy to insulin addition, including HbA1c and body weight reduction outcomes, in addition to other relevant efficacy and safety endpoints, as compared to both placebo and other common antihyperglycemic drugs
Pre-Existing Conditions Not all patients are equally vulnerable
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A post hoc analysis of data from SURPASS-4 showed that tirzepatide is effective in reducing the risk of worsening renal function compared with insulin glargine
The consequent impairment in oxalate homeostasis can trigger localized and systemic inflammation, progressive kidney disease and cardiovascular complications, including sudden cardiac death