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After 56 weeks: Placebo group lost 1.6% of body weight Starting dose (3.75/23 mg) group lost 5.1% of body weight Top dose (15/92 mg) group lost 10.9% of body weight Beyond weight loss, the CONQUER trial showed significant improvements in blood pressure, waist circumference, lipid profiles, glycemic parameters, and inflammatory biomarkers compared to placebo

Kidney function tests monitor for any drug-related stress because GLP-1 medications are primarily excreted by the kidneys

Conversely, the expression of AKT3, an isoform of AKT known for its oncogenic and anti-apoptotic functions 51 , was found to be diminished following the treatment of cancer cells with pDNA/Polybia-MP1

Domain 11: Statistical analysis