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The syntheses of this group of ACE inhibitors have been reported via reductive amination of 2-oxo-4-phenylbutyrate, conjugate addition of amines to ethyl-4-oxo-4-phenylcrotonate followed by reduction, S N 2 displacement of ( R )-2-hydroxybutyric acid-derived triflate intermediates by amines and via asymmetric alkylations [145]
C B12
(2018) 20(Suppl 1):521
The vast majority of the research is on animals, and what works in a lab rat doesn't always work for people seeking proven regenerative medicine solutions
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