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This is typically when participants have reached their target dose and the full pharmacological effect has developed

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Obesity and accompanying visceral adipose tissue inflammation cause insulin sensitivity in mice, a process that appears to be driven by increased hepatic DPP-4 production and release, since abolishing hepatocyte DPP-4 expression reduces inflammation and improves insulin sensitivity

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K.KaragiannopoulosA.BarghouthM.NagaoM.AnderssonM