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These medications, known as GLP-1 receptor agonists (GLP-1-RAs), offer promising therapeutic options for type 2 diabetes and obesity-related conditions, including cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD) (6)
The protein blunts post-meal glucose and triggers GLP-1 release, which increases satiety
It was based on a drug development program with 8 randomized trials: 1 phase 2 dose-ranging (2.5100 mg/d) study
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DOX is a highly toxic molecule and induces drug resistance due to the overexpression of ABCB1 efflux pump and other related proteins 127
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