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Combined use should always follow clinical assessment and should not replace investigation of underlying causes
Frequency is typically once daily for general effects or twice daily for acute conditions, often taken in morning for mental clarity (though timings relevance is unproven)
Ravakhah K et al
[1] [2] This complex absorption mechanism means that deficiency can arise not only from inadequate dietary intake but also from malabsorption disorders
But the brain, muscles, and immune system, which are the highest energy consumers, show the most dramatic functional consequences
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