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Feb 2 2001;84(3):417-422

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Clinical research suggested doses in the range of 1-10mcg per kilogram of body weight showed efficacy, though most protocols standardized around 4-6mcg/kg for practical application

The rationale went beyond convenience: vortioxetine acts through multiple serotonergic mechanisms simultaneouslyserotonin transporter (SERT) inhibition alongside 5-HT1A agonism, 5-HT3 and 5-HT7 antagonism, and 5-HT1B partial agonismgiving it a pharmacological breadth suited to a drug-induced depression where the precipitating mechanism was unlikely to be purely serotonergic ( Bupropion XL 150 mg once daily was added specifically to address the dopaminergic dimension

While pigmentation injections are a powerful tool, they often work best as part of a comprehensive skincare strategy