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It is important to distinguish between expected gastrointestinal symptoms and more serious adverse reactions that may require medical intervention

These reports have been sufficiently concerning that regulatory bodies, including the European Medicines Agency (EMA) and the MHRA, have conducted safety reviews of GLP-1 receptor agonists to assess whether there is a causal link between these medications and suicidal thoughts or self-harm

(PubMed) Egnell M, Fassier P, Lecuyer L, et al

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l-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway