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WIREDs experience ordering these medications suggests that people who do not meet the criteria to get these drugs prescribed will not have a difficult time circumventing the guardrails in place

Evidence that many people may stop their use of obesity drugs not long after starting therapy casts doubt about the sustainability of weight loss to achieve long-term positive health outcomes

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The promoter regions analyzed spanned 2000 to +100 nucleotides relative to the TSS

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