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These, for example, include prodrug strategies, as seen in the case of OTC, which was designed to have improved bioavailability and stability (it is thought of being converted to cysteine intracellularly, which is then used for GSH synthesis) or NAC amide that has improved lipophilicity and cell permeability
Landry, A
Methods 64 , 391397 (2006)
HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo
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