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Intact glutathione is poorly membrane-permeant and extracellular glutathione is degraded by gamma-glutamyl transpeptidase before its amino acids are reimported (Zhang, Forman and Choi, Methods in Enzymology, 2005), whereas cysteine-delivery agents bypass that step
In HCC driven by obesity and nonalcoholic steatohepatitis, the downregulation of CPT2 leads to the accumulation of acylcarnitines, among which C18:1-carnitine enhances spheroid formation by HCC cells through STAT3 activation, indicating that the accumulation of acylcarnitine can promote the development of liver cancer [212]
heart disease, such as coronary heart disease and hypertension
doi: 10.3892/br.2020.1372
Western Blot Analysis RIPA lysis buffer and Bradford Protein Assay Kit were used for protein determination from brain tissues (Bio Basic Inc., Markham, Ontario, Canada)
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