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Because of its dual mechanism, tirzepatide often produces greater average weight loss and stronger blood sugar improvements in many patients
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Nausea is the most common, affecting 13-18% in most studies, often during dose escalation
An increasing body of preclinical and clinical evidence suggests that mitochondrial dysfunction, characterized by bioenergetic failure, heightened oxidative stress, dysregulated calcium handling, and impaired mitophagy, contributes to the etiopathogenesis of both CVDs and cognitive impairment
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