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If the intervals between shots are long enough, this can cause some weight regain, which can be very frustrating for patients, says Meghan Garcia-Webb, MD, a board-certified internal, lifestyle, and obesity medicine physician in private practice in Wellesley, Massachusetts

Wegovy typically takes a few weeks to start showing significant effects

Nakatani Y, Maeda M, Matsumura M, Shimizu R, Banba N, Aso Y, et al

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Lowering the dosage or splitting it into smaller doses throughout the day may help alleviate these symptoms