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In the STEP 3 randomised trial, once weekly semaglutide 2.4 mg used in obese adults without diabetes was associated with 4.9% incidence of gallbladder related disorders (mainly cholelithiasis) compared with 1.5% in the placebo group (1)
It is a quinolinium salt substituted at position 5 with an amino group and at position 1 with a methyl group
Oral semaglutide may be the ideal choice for you if: You have a fear of needles: Trypanophobia (fear of needles) is a major barrier for many patients
In RCTs comparing GLP-1RA and placebo, insulin doses were reduced before GLP-1RA initiation to avoid hypoglycemia, and close monitoring and insulin adjustments were done periodically
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