However, it should not be viewed as a universal solution for fatigue, immunity, weight loss, ageing, or every health concern
Mobilising evidence, data, and resources to achieve global maternal and child undernutrition targets and the sustainable development goals: an agenda for action
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More recently, a small-molecule APJ agonist partnered with BioAge failed in clinical development due to hepatotoxicity unrelated to target engagement, highlighting that off-target toxicity can arise independently of the signaling bias hypothesis (Ryffel et al., 2023)
Additionally, thanks to its role in reducing free radicals, it can provide powerful anti-aging properties by helping reduce signs of aging