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Macrocyclic Mn(II) pentaazamacrocyclic ligands such as M40419 have been shown to decrease oxidative stress and prevent emphysema induced in rats by vascular endothelial growth factor receptor blockade

Bu, F., Zhang, S., Duan, Z., Ding, Y., Chen, T., Wang, R., Feng, Z., Shi, G., Zhou, J., & Chen, Y

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Future studies should focus on exploring their efficacy in different patient groups, evaluating their long-term efficacy and safety, and further refining treatment strategies to fully realize their therapeutic potential [86]