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Preclinical studies suggest that GLP-1 signaling in the central nervous system may influence neuronal activity patterns, though the clinical significance of these findings for human fatigue remains theoretical

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This indicates that Lira can improve liver fatty acid oxidation in obese mice, reduce liver fat accumulation, and promote hepatic lipolysis by activating the liver SIRT1/PGC-1/PEPCK pathway [67]

doi: 10.1016/j.physbeh.2014.02.026 9 AnderbergR