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An influential pricing watchdog, the Institute for Clinical and Economic Review (ICER), gave its highest cost-effectiveness rating to Novo Nordisks semaglutide, sold as Ozempic and Wegovy, and Eli Lillys tirzepatide, marketed as Mounjaro and Zepbound

Some of the most common questions about giving IM injections include: Do You Pinch the Skin for an IM Injection

This makes it even more important to manage side effects proactively

Trials to date have focused on weight and metabolic outcomes, with lean mass reduction typically reported as a secondary endpoint and without standardized functional measures

Patients should be alert to symptoms such as severe upper abdominal pain (potentially radiating to the back), fever, jaundice, or persistent vomiting, which require urgent medical assessment