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If side effects persist and remain intolerable despite extended up-titration, a lower maintenance dose may be considered to support adherence and reduce the risk of treatment discontinuation [66]
It breaks down whatever tissue is available
For veterans in the study with a pre-existing substance-use disorder, starting a GLP-1 drug was associated with 31% fewer emergency department visits related to their addiction, 26% fewer hospital admissions, a halving of deaths, 39% fewer overdoses and a 25% reduction in suicidal ideation or attempts
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