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10.1016/S0092-8674(00)81203-9 481 De Michele G., De Fusco M., Cavalcanti F., Filla A., Marconi R., Volpe G., Monticelli A., Ballabio A., Casari G., Cocozza S., A new locus for autosomal recessive hereditary spastic paraplegia maps to chromosome 16q24.3
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PMC 11107735
In humans, the rate of taurine synthesis from methionine and cysteine is exceedingly low in comparison with rats (Sturman 1993), because the activity of hepatic cysteinesulfinate decarboxylase (a key enzyme in taurine synthesis) is about three orders of magnitude lower in the young and adult men than that in rats (Sturman and Hayes 1980)
This means it may take several weeks of consistent use before you notice a visible difference in skin brightness or tone
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