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387 Pegloticase, a recombinant urate oxidase conjugated to polyethylene glycol (PEG), has been introduced to reduce immunogenicity and extend the half-life of rasburicase

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Acknowledgements This work was supported by Fundao para a Cincia e a TecnologiaFCT, European Union, QREN, FEDER, and COMPETE for funding the UnIC (UIDB/IC/00051/2020 and UIDP/00051/2020), RISEHealth Research Network-From the Lab to the Community (LA/P/0053/2020), and the research project 2022.04344.PTDC (SEXDIFEND

Interestingly, the addition of zinc in non-toxic concentrations significantly enhances the Treg-inducing capacity of DCs, offering a promising therapeutic strategy for immune-mediated diseases [271]