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Oral administration is more likely to induce adverse events in the gastrointestinal system
In another context of reward alterations, i.e., the chronic unpredictable mild stress (CUMS), the supplementation in propionate intra-rectally, restore the sucrose preference, together with the concentration of dopamine in the prefrontal cortex of rats (Li et al., 2018)
Slower titration significantly reduces both the severity and duration of these side effects
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