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Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes

Combining compounds multiplies the number of potential side effects at play, and stacking unapproved research chemicals without medical supervision carries meaningfully more risk than using a single compound on its own

doi: 10.1038/ejcn.2017.132.

While it is generally safe for short-term use, the long-term effects are not well understood