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None of that makes them useless
It has high biological activity
In the 50s, when chemotherapy wasnt yet available, massive doses of B12 shots were given to children with a neuroblastoma tumor every two days, for 2-3 years with great success: NEUROBLASTOMA: AN EVALUATION OF ITS NATURAL HISTORY AND EFFECTS OF THERAPY, WITH PARTICULAR REFERENCE TO TREATMENT BY MASSIVE DOSES OF VITAMIN B12
However, recognising when symptoms warrant further assessment ensures safe, effective treatment
More time in deep sleep means more physical recovery, better memory consolidation, and lower baseline cortisol
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