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Phase I: Transformation In this first stage, enzymes (specifically the cytochrome P450 family) begin to break down toxins

10.1073/pnas.0505294102 Proc

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The other is efflux transporters, which are generally ATP-binding cassette transporters, such as P-glycoprotein and breast cancer resistance protein (BCRP)

The reduction in nitrite levels is particularly significant as excessive nitric oxide can form peroxynitrite, a potent neurotoxic compound 30