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Research has also examined its role in upregulating matrix metalloproteinase (MMP) activity alongside their inhibitors (TIMPs), suggesting a finely balanced role in extracellular matrix remodelling rather than simple collagen deposition

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Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl (BPTES), a potent orally available GLS1 inhibitor that spares GLS2, shows promising antitumor effects against human lymphoma B cells in vitro and in a xenograft mouse model 42

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