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6.2 Novo Nordisk + Septerna (May 2025, up to $2.2B) Novo's second major triple-agonist transaction was a broader small-molecule GPCR collaboration with Septerna announced May 2025: up to $2.2 billion total deal value, $200 million+ upfront, covering four oral small-molecule GPCR programs

Endurance capacity Animal studies showed 70% increase in exercise endurance - the standout finding behind the "exercise mimetic" label

Skip AHAs, BHAs, and other retinoids while using tretinoin

Long R3 IGF-1 has been studied and used for many years as a growth-supporting supplement in serum-free and reduced-serum media, including in industrial mammalian expression systems, where the practical questions are how much of it survives in medium over a culture cycle, whether it can substitute for insulin at far lower molar input, and how it interacts with the binding proteins that cells themselves secrete into conditioned medium

It works best when combined with adequate hydration, nutrition, and reducing ongoing toxin exposure