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The long-term efficacy of Semaglutide (used in Ozempic and Wegovy ) and Mounjaro (tirzepatide) in weight maintenance has been a subject of continuous study and interest within the medical community
After 72 weeks Mounjaro caused an average weight loss of 22.5%, while Wegovy 7.2mg caused an average weight loss of 21% in the same time frame
2025 1 ,
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In fact, the opposite was discovered, and GLP-1R agonism was found to significantly reduce expression of hepatic Cyp2e1 independently of nutrient and ethanol intake, with the predictable consequence of higher serum ethanol levels after a fixed ethanol dose
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