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Dapagliflozin and new-onset type 2 diabetes in patients with chronic kidney disease or heart failure: pooled analysis of the DAPA-CKD and DAPA-HF trials

2.6 Therapeutic perspectives Ferroptosis integrates multiple metabolic pathways: (1) iron catalysis driving hydroxyl radical formation, (2) lipid metabolism determining peroxidation substrates, (3) thiol metabolism maintaining the redox environment, and (4) selenium metabolism enabling selenoprotein-based detoxification

In an experimental study performed in 5/6 nephrectomized normo- and hyperuricemic rats, febuxostat protected against renal damage, and prevented proteinuria, preserving vessel morphology and glomerular pressure, thus it prevents progression of CKD independently of its effect on UA.46 In the FOCUS47 extension study, 116 patients treated with febuxostat were followed for 5 years

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It should also provide a thorough initial intake consultation as well as ongoing support during your treatment