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It activates the Keap1/Nrf2 signaling pathway in a dose-dependent manner, inducing Nrf2 nuclear translocation and increased ARE-driven transcriptional activity, leading to upregulation of VSMC cell cycle-dependent kinase inhibitor p27kip1 expression and proliferation inhibition [173]

USA 103 , 1514815153 (2006)

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This is particularly powerful because it can reveal mechanisms of action that weren't previously suspected