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Although environmental factors such as diet, lifestyle, medication exposure, and metabolic status are major determinants of the gut microbiota, host genetic variation can influence intestinal physiology, immune regulation, bile acid metabolism, epithelial barrier integrity, lipid handling, and inflammatory responses, thereby shaping the ecological conditions in which microbial communities develop (Wu et al., 2023, 2021

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As shown in Table 2, the 90% CI for the ratio of IcoSema/icodec was fully contained within the range of 80125% for total icodec exposure after single dose (AUC 0 t ,SD,Icodec ), suggesting similar relative bioavailability of icodec following IcoSema administration and icodec administration alone

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