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Thus, according to patent literature the drug-like 8 and 9 exhibit a very high affinity to the Ang IV binding site named the AT4 receptor
Still, these molecules also have multiple GSH-independent functions, which can potentially confound interpretations
This application is still primarily investigational and is explored within structured clinical protocols
Even so, it comes with notable side effects when you consider the injectable form
Overall, the results indicate that repeated sub-chronic exposure to paracetamol and ibuprofen at therapeutic-equivalent dose ranges may be associated with early hematological, histological, and molecular alterations in mice
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