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p62 competes with NRF2 for binding to KEAP1, and this interaction induces a dependent autophagic degradation of KEAP1 and subsequent NRF2 stabilization and activation in both MEFs and HEK293 cells [198]
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the incretins are studied for their well-documented whole-organism metabolic effects
Mice fed MOTs-C performed significantly better in endurance and speed as compared to those in the lower dose and control groups.6 Studies in rats have similarly found improved myocardial mechanical efficiency with MOTs-C supplementation
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